Among 1735 women, each 10 pack-years of smoking was associated with a ?0.85% (95% CI ?1.13% to ?0.57%) mean decrement in FEV1 to FVC ratio, a ?48.6 ml (95% CI ?61.6 to ?35.7) mean decrement in FEV1 and a 1.36 (95% CI 1.20 to 1.55) increase in the odds of airflow obstruction. Plots of the relationship of pack-years to FEV1 to FVC ratio showed similarly linear relationships for racial/ethnic groups (see online supplementary figure S1B).
There was no evidence that the relationship of pack-years to FEV1, FEV1 to FVC ratio or airflow obstruction differed by genetic ancestry among Caucasian, African-American and Hispanic women (table 3). Chinese-American women were excluded from this analysis given the very small number with a smoking history. Similarly, there was also no evidence for effect modification by self-reported race/ethnicity among women (table 3).
Mean difference in lung function as well as having airflow congestion for each 10 prepare-numerous years of puffing certainly one of ladies, stratified of the battle/ethnicity
Among African-American and Hispanic women, there was no evidence for any interaction between pack-years and proportion African ancestry and, among Hispanics, Native American ancestry for the FEV1 or FEV1 to FVC ratio (all p>0.05).
Collective smoking and % emphysema
Characteristics of 8247 participants included in the analyses of per cent emphysema are shown in online supplementary table S1. Among women, every 10 pack-years of smoking were associated with a 0.43% increase in per cent emphysema (p<0.001). Among men, 10 pack-years of smoking was associated with a 0.10% increase in per cent emphysema, though the association was not statistically significant (p=0.30). There was no evidence that this association differed by genetic ancestry among men or women, although in women there was a suggestion of effect modification by self-reported race/ethnicity (p=0.03; online supplementary table S2). Furthermore, there was no evidence that the association of pack-years to per cent emphysema varied by continental ancestry among African-American and Hispanic women and men (p>0.16).
Awareness analyses
Among 1255 men and women with a history of smoking greater than 10 pack-years (mean pack-years 36, SD ±26), there was also no evidence of that the relationship of pack-years to FEV1, FEV1 to FVC ratio or airflow obstruction differed by self-reported race/ethnicity or genetic ancestry (see online supplementary table S3). Continue reading “Hereditary ancestry, cumulative smoking and lung setting one of ladies”